Aim and objective: Saliva contains different enzymes, which reflect metabolic activities of the body. Certain enzymes, such as, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes are products of cell injury and cell death. Some benign oral conditions having malignant potential and therefore early changes in salivary enzyme level may be helpful for the early detection of malignancy. An attempt is made to compare salivary enzyme levels (AST and ALT) in benign oral lesions in tobacco addicts, malignant oral lesions in tobacco addicts, and healthy non-tobacco addict patients with age- and sex-matched control group.
Material and methods: A retrospective study of 150 patients with benign and malignant oral lesions with tobacco addiction was done. Control group includes tobacco non-addicts. The oral lesion was noted. Biopsy of oral lesion was sent to histopathology for diagnosis. The saliva of all patients was collected for salivary enzymes (AST and ALT) examination. Levels of salivary enzymes (AST and ALT) in benign and malignant oral lesions of patients with tobacco addiction and tobacco non-addict control group without any oral lesions with age- and sex-matched study group were included in the study. The results were analyzed statistically by Student\'s t-test.
Results: Salivary enzymes (AST and ALT) were not significantly increased in benign and malignant oral lesions in tobacco addict patients.
Conclusion: Salivary enzymes were increased in all benign and malignant oral lesions in tobacco consumers. There was no significant increase in salivary enzymes in all benign and malignant oral lesions in tobacco consumers.
Clinical significance: Research is going on salivary biomarkers, but these salivary biomarkers lack sensitivity and specificity and cannot be applied.
Muhammet Fatih Topuz,
Schwannoma is a benign, asymptomatic, solitary, and encapsulated tumor that grows slowly from peripheral, autonomic, or cranial nerve sheaths. The origin of the schwannomas in the facial nerve is rare and they tend to occur in the intratemporal part of the nerve. An intraparotid facial nerve schwannoma is usually a painless, slow-growing mass like the other benign parotid tumors. In this case report, we will discuss the clinical presentation, management, and outcome of two patients with intraparotid facial nerve schwannoma.
Rana K Sherwani
How to cite this article:
Afroz N, Rabindranath D, Quadri S, Sherwani RK. Facial Plexiform Neurofibroma as an Intraparotid Nodule: A Rare Case Presentation. Int J Otorhinolaryngol Clin 2020; 12 (1):8-10.
Neurofibromas of salivary gland are very rare and account for only 0.4% of all salivary gland neoplasms. Plexiform type of neurofibromas are predominantly seen in a scenario of neurofibromatosis-1 (NF-1) association, but solitary plexiform neurofibroma has also been occasionally reported. We present a report of this variant in a 17-year-old male who is presented with a slow-growing painless swelling in the right preauricular region for 8-month duration. Microscopic examination revealed multiple cell types including Schwann cells, perineurial cells, axons, lymphocytes, mast cells, and endoneurial fibroblasts. Immunostaining with S100 confirmed the neural origin.
Seema R Gupta,
Vandana P Thorawade,
Mohammad Hanif MS Khan
Introduction: Pleomorphic adenoma of minor salivary glands of the hard palate is a rare benign tumor that has elements of both epithelial and mesenchymal tissues. It usually presents as slow-growing painless submucosal mass on the hard palate. Diagnosis rests on clinical features and tissue examination with radiological investigations helping in surgical planning.
Aim and objective: To add to the literature few more cases of this relatively rare condition and discuss its clinical presentation and management.
Case description: Here, we present a case series of three patients who presented with a mass over the hard palate that was subsequently diagnosed as pleomorphic adenoma and discuss the treatment of the same.
Conclusion: Treatment of choice is wide local excision with removal of periosteum or bone if involved. Recurrence rate is low.
Bela J Prajapati,
Devang P Gupta,
Viral J Prajapati,
Chaitry K Shah
How to cite this article:
Prajapati BJ, Gupta S, Gupta DP, Prajapati VJ, Shah CK. An Unusual Giant Pleomorphic Adenoma of Submandibular Salivary Gland: A Rare Case Report. Int J Otorhinolaryngol Clin 2020; 12 (1):14-16.
Pleomorphic adenoma is the most common benign tumor of salivary glands. Eighty percent of pleomorphic adenomas occur in the parotid gland, 10% in the submandibular gland, and 10% in minor salivary glands and sublingual glands. In this case report, we aim to present the unusually giant presentation of submandibular gland pleomorphic adenoma and its management of a 52-year-old female patient who presented to us with a swelling in the right submandibular region for the last 5 years. Fine needle aspiration cytology (FNAC) suggested salivary gland origin. Ultrasonography of the neck revealed a well-defined large lobulated heterogeneous echotexture lesion with few cystic areas within and showing internal vascularity in the right submandibular region. Computed tomography (CT) scan revealed a large lobulated heterogeneously enhancing mass of 15 cm × 13 cm in the right submandibular region. The patient underwent right submandibular gland mass excision under general anesthesia. The patient presented good aesthetic and functional results with no clinical and radiographic evidence of recurrence. Being painless and slowly growing, some patients neglect it to such large sizes especially if surgery was a psychological setback for them which can then lead to facial disfigurement and severe pressure symptoms which may be fatal. Giant pleomorphic adenoma of the submandibular gland is a rare finding and should be diagnosed cautiously. Proper treatment is complete surgical excision with removal of the fibrous capsule so as to prevent recurrence.
The tumors of the salivary gland are rare but the most common is pleomorphic adenoma (PA). Since PA is asymptomatic, it is ignored by the patients until they are cosmetically bothered. A 57-year-old male presented to us with a large growth on the right side of the face, which enlarged gradually over a period of over 10 years. The excised specimen was 27 cm × 17 cm × 10 cm in dimensions and 2.250 kg in weight.