An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 5 , ISSUE 3 ( Number, 2013 ) > List of Articles

CASE REPORT

Aggressive Metastasizing Pleomorphic Adenoma— A Wolf in Sheep's Clothing: A Case Report with Review of Literature

RF Chinoy, D Dalmia, RS Mundhe, MA DeSouza, V Rane

Citation Information : Chinoy R, Dalmia D, Mundhe R, DeSouza M, Rane V. Aggressive Metastasizing Pleomorphic Adenoma— A Wolf in Sheep's Clothing: A Case Report with Review of Literature. Int J Otorhinolaryngol Clin 2013; 5 (3):28-32.

DOI: 10.5005/aijoc-5-3-28

License: CC BY-NC 3.0

Published Online: 01-08-2011

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Metastasizing pleomorphic adenoma (MPA) is a rarity, and detailed immunohistochemistry (IHC) work-up is being documented in this case. Most cases present with metastasis after a period of several years, ranging from 1.5 to 51 years. The present case deals with a morphologically and immunologically benign pleomorphic adenoma of the parotid, behaving in a paradoxically aggressive fashion at the local site, at the time of initial diagnosis. Regional nodal metastasis and significant local perineural and intraneural infiltration were identified at presentation. In view of the strong tumor neural affinity, the differential diagnosis included an atypical tubular form of adenoid cystic carcinoma (ACC). However, ACC was ruled out on morphology and by IHC. Literature is reviewed and the varied spectrum of reported cases is briefly put forth.


PDF Share
  1. Salivary gland tumors. In: Fletcher CDM editor. Diagnostic Histopathology of tumors. 3rd ed. 2007;1:239–325.
  2. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 2006;132(7):788–793.
  3. Significance of the expression of tumor markers in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland. Korean J Otorhinolaryngol Head- Neck Surg 2008;Apr51(4):336–342.
  4. Metastasizing Pleomorphic Adenoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organisation Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. Lyon, France: IARC Press, 2005;245.
  5. Metastasizing pleomorphic salivary adenoma should now be considered a low-grade malignancy with a lethal potential. Current Opinion in Otolaryngology and Head and Neck Surgery 2005 Apr;13(2):123–126.
  6. Case Report Metastasizing Pleomorphic Adenoma: A Fascinating Enigma. Case Reports in Medicine; Volume 2012 (2012), Article ID 148103;p5.
  7. Clinically aggressive metastasizing pleomorphic adenoma: report of two cases. Head and Neck 1997; Oct19(7):629–633.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.