Very few cases of spontaneous malignant transformation of nonirradiated recurrent juvenile laryngeal papillomatosis (JLP) have been reported in literature. We document a case of invasive laryngeal carcinoma arising in pre-existing juvenile laryngeal papillomatosis. After multiple CO2 Laser resections, a 29-year-old female, non-smoker, who had never received radiation therapy, developed a florid exophytic transglottic squamous cell carcinoma. Therefore, regular extensive biopsies and careful histopathological examination are required in cases of JLP. We also emphasize the need to maintain a high index of suspicion for malignant transformation in long standing cases.
Papillomas of the larynx in children: A clinicopathologic study. Am J Surg 1964;108: 470–75.
Laryngeal epidermoid carcinoma associated with juvenile laryngeal papillomatosis. Laryngoscope 1985;95:1264–66.
Molecular transformation of recurrent respiratory papillomatosis: Viral typing and p53 overexpression. Ann Otol Rhinol Laryngol 2003;112:298–302.
Squamous cell carcinoma of the respiratory tract following laryngeal papillomatosis. Acta Otolaryngol 1994;114:209–12.
Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p53. Laryngoscope 1998;108:735–40.
High-risk human papillomavirus types and squamous cell carcinoma in patients with respiratory papillomas. Otolaryngol Head Neck Surg 1999;120:698–705.
Laryngeal epidermoid carcinoma associated with juvenile laryngeal papillomatosis. Laryngoscope 1985;95:1264–66.
Human papillomavirus infection in the etiology of laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 2004;12:88–92.
Human papillomavirus in Larynx. Laryngoscope 2002;112:700–07.
A systemic review of case-control studies of human papillomavirus infection in laryngeal squamous cell carcinoma. Clin Otolaryngol 2004;29:301–06.
Human papillomavirus (HPV) in head and neck cancer. J Clin Virol 2005;32S:S59–S66.
Papillomavirus Infections in Human Disease. New York: Wiley, 2000:1–615.
Head Neck 29(2):155–62.
High Incidence of Malignant Transformationof Laryngeal Papilloma in Taiwan. Laryngoscope 118: January 2008;50–55.
Human papillomavirus- 11–associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus- 6–associated disease. Pediatr Dev Pathol 2001;4:68–72.
Integration of human papillomavirus type 11 in recurrent respiratory papilloma– associated cancer. Laryngoscope 2004;114:1906–09.
Papilloma of larynx with Intrepithelial Anaplastic Changes. Arch Otolaryngol 1955;62: 478–85.
Malignant transformation of benign laryngeal papillomas in children after radiation therapy. Surg Clin North Am 1963;43:1049–61.
Recurrent respiratory papillomatosis with malignant transformation in a young adult. Respir Med 1996;90(1):53–55.
Treatment of recurrent respiratory papillomatosis with human leukocyte interferon. Results of a multicenter randomized clinical trial. N Engl J Med 1988 Aug 18;319(7):401–07.