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VOLUME 15 , ISSUE 3 ( September-December, 2023 ) > List of Articles

CASE REPORT

Nasopharyngeal Amyloidosis Extending to Larynx: A Rare Clinical Presentation

Jahnavi, Honey Ashok

Keywords : Amyloidosis, Case report, Coblation, Congo red stain, Flexible video laryngoscopy

Citation Information : Jahnavi, Ashok H. Nasopharyngeal Amyloidosis Extending to Larynx: A Rare Clinical Presentation. Int J Otorhinolaryngol Clin 2023; 15 (3):136-138.

DOI: 10.5005/jp-journals-10003-1460

License: CC BY-NC 4.0

Published Online: 09-01-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Aim: Nasopharyngeal amyloidosis is rare, with very few reports in the literature. We report a case of amyloidosis of the nasopharynx extending into the larynx mimicking a tumoral process and compromising the airway, a unique clinical presentation. Background: Amyloidosis is a condition characterized by the deposition of extracellular proteinaceous material, resulting in damage to the tissues. A total of 19% of cases involve the head and neck with the oropharynx and larynx being the most affected organs. Localized amyloidosis is a rare and slow-growing lesion and is considered benign tumor, but it may be aggressive locally. Case description: A 49-year-old female presented with voice change and breathlessness. On clinical evaluation, multiple swellings involving the nasopharynx and larynx compromising the airway were noticed and a biopsy was done, which confirmed our primary clinical suspicion of Amyloidosis and was planned for staged coblation-assisted excision of the lesions to secure adequate airway. Conclusion: A complete clinical and paraclinical work-up is required for the positive diagnosis of primary or secondary amyloidosis. Morbidity is high so postsurgical follow-up is essential. Clinical significance: The localized form usually follows a slow and benign clinical course with a favourable prognosis of 90.6%. The principal differential diagnosis is a malignant tumor, hence the importance of histopathologic diagnosis. The recurrence rate approximates zero, but the extremely rare presentation and slow progression of this pathology make surveillance mandatory.


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