Microbiome Profile in Chronic Rhinosinusitis with and without Polyps of Makassar, Indonesia
Azmi Mir ah Zakiah, Muhammad Fadjar Perkasa, Amelia Dian Utami, Riskiana Djamin, Burhanuddin Bahar, Firdaus Hamid, Abdul Qadar Punagi
Citation Information :
Zakiah AM, Perkasa MF, Utami AD, Djamin R, Bahar B, Hamid F, Punagi AQ. Microbiome Profile in Chronic Rhinosinusitis with and without Polyps of Makassar, Indonesia. Int J Otorhinolaryngol Clin 2019; 11 (3):55-63.
Background: Chronic rhinosinusitis (CRS) is a prevalent health problem that results in a large costly burden in society is often associated with the role of the microbiome that seems to maintain a healthy state and stability of the sinonasal environment often viewed as a symbiotic system. Aim and objective: This study aimed to identify a microbiome profile in chronic rhinosinusitis with and without nasal polyps of Indonesian population. Materials and methods: This study was conducted using the case-control technique on 20 patients divided into two groups. The first group is CRS without nasal polyps consisted of 10 patients and the second group is CRS with nasal polyps consisted of 10 patients. All of the samples were examined by next-generation sequencing techniques. Results: Microbes were detected in all samples. Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, Fusobacteria, and Proteobacteria were the dominant phylum in both groups with a variable number of percentages. Conclusion: This study highlights alteration of the commensal microbe may lead to dysbiosis conditions of the sinonasal environment.
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