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VOLUME 5 , ISSUE 3 ( Number, 2013 ) > List of Articles


Aggressive Metastasizing Pleomorphic Adenoma— A Wolf in Sheep's Clothing: A Case Report with Review of Literature

RF Chinoy, D Dalmia, RS Mundhe, MA DeSouza, V Rane

Citation Information : Chinoy R, Dalmia D, Mundhe R, DeSouza M, Rane V. Aggressive Metastasizing Pleomorphic Adenoma— A Wolf in Sheep's Clothing: A Case Report with Review of Literature. Int J Otorhinolaryngol Clin 2013; 5 (3):28-32.

DOI: 10.5005/aijoc-5-3-28

License: CC BY-NC 3.0

Published Online: 01-08-2011

Copyright Statement:  Copyright © 2013; The Author(s).


Metastasizing pleomorphic adenoma (MPA) is a rarity, and detailed immunohistochemistry (IHC) work-up is being documented in this case. Most cases present with metastasis after a period of several years, ranging from 1.5 to 51 years. The present case deals with a morphologically and immunologically benign pleomorphic adenoma of the parotid, behaving in a paradoxically aggressive fashion at the local site, at the time of initial diagnosis. Regional nodal metastasis and significant local perineural and intraneural infiltration were identified at presentation. In view of the strong tumor neural affinity, the differential diagnosis included an atypical tubular form of adenoid cystic carcinoma (ACC). However, ACC was ruled out on morphology and by IHC. Literature is reviewed and the varied spectrum of reported cases is briefly put forth.

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