An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 5 , ISSUE 2 ( Number, 2013 ) > List of Articles


A Series of Two Cases of Intraoral Malignancies in Patients with Xeroderma Pigmentosa

Ankit Dilip Mahuvakar, Darshan Premdas Meshram, Vijayalaxmi Kisanrao Ambulgekar, Mohsin Abdul Nabi Shaikh, Mohammad A Sameer

Citation Information : Mahuvakar AD, Meshram DP, Ambulgekar VK, Shaikh MA, Sameer MA. A Series of Two Cases of Intraoral Malignancies in Patients with Xeroderma Pigmentosa. Int J Otorhinolaryngol Clin 2013; 5 (2):21-24.

DOI: 10.5005/aijoc-5-2-21

License: CC BY-NC 3.0

Published Online: 01-08-2011

Copyright Statement:  Copyright © 2013; The Author(s).


Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by an increased frequency of skin cancer following minimal sunlight exposure.

Multiple basal cell carcinomas and other skin malignancies frequently occur at a young age in those with XP. In fact, metastatic malignant melanoma and squamous cell carcinoma are the two most common causes of death in XP victims.

This series represent rare presentations of malignancies in non-sun-exposed areas in such patients.

PDF Share
  1. Defective repair replication of DNA in xeroderma pigmentosum. Nature 1968 May;218(5142):652–656.
  2. Xeroderma pigmentosum, an inherited disease with sun sensitivity, multiple cutaneous neoplasia and abnormal DNA repair. Ann Inter Med 1974 Feb;80(2):221–248.
  3. ; Kaposi, M. On disease of skin including the exanthemata. London: The New Sydenham Society; 1874. 252–258 p.
  4. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987 Feb;123(2):241–250.
  5. Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. Br J Radiol 2006 Jun;79(942):510–517.
  6. Studies on a new case of xeroderma pigmentosum (XP 3BR) from complementation group G with cellular sensitivity to ionizing radiation. Carcinogenesis 1980 Sep;1(9):745–751.
  7. ; Gilbert, Ralph W. Stell and Maran's textbook of head and neck surgery and oncology. 5th ed. India: CRC Press; 2012.
  8. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell 2001 Dec;8(6):1187–1196.
  9. Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization. Genes Chromosomes Cancer 1998 Nov;23(3):213–219.
  10. Functional retroviral vector for gene therapy of xeroderma pigmentosum group d patients. Hum Gene Ther 1995 Oct;6(10):1307–1315.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.