An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 3 , ISSUE 1 ( January-April, 2011 ) > List of Articles

REVIEW ARTICLE

The Role of Radiotherapy in the Management of Paraganglioma

Mark Trombetta

Keywords : Glomus tumors,Paraganglioma,Radiation,Chemodectoma

Citation Information : Trombetta M. The Role of Radiotherapy in the Management of Paraganglioma. Int J Otorhinolaryngol Clin 2011; 3 (1):25-29.

DOI: 10.5005/jp-journals-10003-1051

Published Online: 01-04-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Paragangliomas or glomus tumors are usually low-grade hypervascular tumors occurring in various sites of the autonomic nervous system including the carotid body, glomus vagale and glomus tympanicum. Although the grading of the tumor suggests a benign clinical course, the tumor can be locally malignant and surgical management is sometimes difficult because of postoperative functional loss and local recurrence. In addition, the operative field is generally very bloody and tissue planes are not always well-defined.

Though the optimal management of paraganglioma occurs in a multidisciplinary setting, considering the excellent local control rates with primary irradiation alone, a nonsurgical definitive approach should initially be considered.


PDF Share
  1. Paragangliomas: Classification, pathology and differential diagnosis. Otolaryngol Clin North Am 2001;34:845–62.
  2. Paraganglioma with pulmonary metastases: A case report. Journal Article, Annals of the Academy of Medicine, Singapore 1996;25(4):592–95.
  3. Malignant paraganglioma with skeletal metastases and spinal cord compression: Response and palliation with chemotherapy. Clinical Oncology (Royal College of Radiologists). 1993;5(2):126–28.
  4. The neurological importance of tumours of the glomus jugulare. Brain 1953;76:576–93.
  5. Carotid body tumor of the middle ear and mastoid. Arch. Otolaryngol 1945;41:64–67.
  6. Diagnosis and management of catecholamine secreting glomus tumors. Laryngoscope 1984;94:1008–15.
  7. Surgery for glomus tumors: The otology group experience. Laryngoscope 1993;103(Suppl 60):65–70.
  8. A gene subject to genomic imprinting and responsible for hereditary paragangliomas maps to chromosome 11q23-qter. Hum Mol Genet 1992;1:7–10.
  9. The basic science of glomus jugulare tumors. Neurosurg Focus 17(2):E2,2004.
  10. Vagal paraganglioma: A review of 46 patients treated during a 20- year period. Arch Otolaryngol Head Neck Surg 1998;124: 1133–40.
  11. Diagnosis and management of paragangliomas of the skull base. Am J Surg 1990;159:389–93.
  12. Glomus jugulare tumors revisited: A ten-year statistical follow-up of 231 cases. Laryngoscope 1985;95: 284–88.
  13. Head and neck paragangliomas: Physiology and biochemistry. Otolaryngol Clin North Am 2001;34:837–44.
  14. Glomus tympanicum and glomus jugulare tumors. Otolaryngol Clin North Am 2001;34:941–70.
  15. J Nat Cancer Inst 1982;68:573–78.
  16. Cancer: Principles and practice of oncology (7th ed). Philadelphia, Lippincott Williams and Wilkins 2005;1875–76.
  17. The paraganglionic chemoreceptor system: Physiology, pathology, and clinical medicine. New York, Springer-Verlag 1982.
  18. Infratemporal fossa approach for extensive tumors of the temporal bone and base of skull. In Silverstein H, Norrell H (Eds). Neurological Surgery of the Ear. Birmingham Al, Aesculapius 1977;34–53.
  19. Surgical treatment of glomus jugulare tumors with special reference to the diagnostic value of retrograde jugulography. Acta Otolaryngol 1965;60:150–68.
  20. Glomus tumors of the temporal region: Technique of surgical resection. Arch Otolarygol 1981;107: 209–14.
  21. Technique for removal of glomus jugulare tumors. Arch Otolaryngol 1964;79:219–24.
  22. The neurosurgical treatment of glomus jugulare tumors. J Nerosurg 1971;35:59–64.
  23. Surgery for large glomus jugulare tumor: The combined suboccipital, transtemporal approach. Arch Otolaryngol 1971;93:227–31.
  24. Glomus tumors: Diagnosis, classification, and management of large lesions. Arch Otolaryngol 1982;108:401–06.
  25. Malignant glomus tumors. Laryngoscope 1999;109:30–34.
  26. The role of radiation therapy in the treatment of chemodectomas of the glomus jugulare. Laryngoscope 1965;75:1861–71.
  27. Cervical paragangliomas: Tumor control and long-term functional results after surgery. Skull Base 2006;16:185–92.
  28. Does Shamblin's classification predict postoperative morbidity in carotid body tumors?A proposal to modify Shamblin's classification. Eur Arch Otorhinolaryngol 2006;263(2):171–75.
  29. The multidisciplinary management of paragangliomas of the head and neck, Part 2: Oncology 2003;17(6):1143–53.
  30. Definitive radiotherapy in the management of chemodectomas arising in the temporal bone, carotid body, and glomus vagale. Head and Neck May 2001;363–71.
  31. Optimum dose of radiotherapy for chemodectomas of the middle ear. Int J Radiat Oncol Biol Phys 1980;6:815–19.
  32. Radiation therapy of the glomus jugulare tumor. AJR 1973;118:663–69.
  33. Glomus jugulare tumors: A series of 21 cases. J Laryngol Otol 1975;89:1113–21.
  34. Chemodectoma of the temporal bone: A comparison of surgical and radiotherapeutic results. Int J Radiat Oncol Biol Phys 1988;14:643–48.
  35. The treatment of glomus tumors in the temporal bone by megavoltage radiation. Cancer 1984;53:2635–40.
  36. Chemodectomas arising in temporal bone structures. Laryngoscope 1982;92: 188–91.
  37. Long-term results after radiosurgery for benign intracranial tumors. Neurosurgery 2003;53:815–22.
  38. Glomus jugulare tumors. Cancer 1992;69(7):1813–17.
  39. Chemodectoma of the head and neck: Results of treatment in 84 patients. Int J Rad Oncol Biol Phys 1992;22:919–24.
  40. Comparison of radiosurgery and conventional surgery for glomus jugulare tumors. Neurosurg Focus 2004;E4 17(2).
  41. Stereotactic radiosurgery in patients with glomus jugulare tumors. Neurosurg Focus 2004;17(2):E10.
  42. Efficacy and safety of stereotactic radiosurgery for glomus tumors. Neurosurg Focus 2004;2:E11.
  43. Radiation therapy of glomus jugulare tumors. Laryngoscope 1993;103(suppl 60):23–27.
  44. A 15-year experience with chemotherapy of patients with paraganglioma. Cancer 1995;76:1476–80.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.