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VOLUME 2 , ISSUE 3 ( September-December, 2010 ) > List of Articles

REVIEW ARTICLE

Chemoradiation for Laryngeal Cancer: Present Scenario

Adwaita Gore, Pushkal Dwiwedi, Boman Dhabhar, Tapan K Saikia

Keywords : Cetuximab,Radiotherapy,Chemoradiation,EGFR,Laryngeal cancer,Head and neck cancer

Citation Information : Gore A, Dwiwedi P, Dhabhar B, Saikia TK. Chemoradiation for Laryngeal Cancer: Present Scenario. Int J Otorhinolaryngol Clin 2010; 2 (3):215-221.

DOI: 10.5005/jp-journals-10003-1039

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

The management of locally advanced squamous cell carcinoma of the larynx is complex. Data from recent clinical trials have refined the use of existing therapies, such as radiation therapy and chemotherapy, and providing new treatment options, such as cetuximab. Selecting the most appropriate treatment for an individual patient requires a multidisciplinary approach and careful assessment of the relative advantages and disadvantages of each treatment approach. Chemoradiation is more effective than conventional radiation therapy, but also more toxic. Cetuximab plus radiation therapy is more effective than radiation alone and does not substantially increase radiation-related toxicity. Multimodality approach for laryngeal cancer has shown better organ preservation rates and survival. Ideally, multidisciplinary teams should weigh all these factors when making individual treatment decisions. Data from current trials will help further optimize multimodality treatment for Laryngeal Cancer.


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