Total laryngectomy since it was first performed more than a century ago has undergone numerous modifications with increasing attention to voice restoration. Function preservation has also been achieved by voice sparing surgical procedures, and organ preservation strategies with chemoradiotherapy for laryngeal carcinoma. However, total laryngectomy remains the standard of care for very advanced laryngeal cancers with cartilage destruction, and as a salvage procedure for failures to organ preservation therapies. In this article, we review the indications, complications and outcomes of total laryngectomy in the era of chemoradiotherapy.
Stomal recurrence after laryngectomy: Interrelated risk factor study. Otolaryngol Head Neck Surg 1990;103[5(Pt 1)]:805–12.
Paratracheal lymph node dissection for carcinoma of the larynx, hypopharynx, and cervical esophagus. Otolaryngol Head Neck Surg 1993;108(1):11–17.
Surgical salvage for stomal recurrence: A multi-institutional experience. Laryngoscope 1987;97(9): 1025–29.
Long-term results of concurrent polychemotherapy and radiotherapy in patients with stomal recurrence after total laryngectomy. Ann Otol Rhinol Laryngol 1986;95(6 Pt 1):572–75.
Life after total laryngectomy: A measure of long-term survival, function, and quality of life. Arch Otolaryngol Head Neck Surg 2007;133(6):526–32.
Clinical outcome following total laryngectomy for cancer. ANZ J Surg 2003;73(5):300–05.
Salvage surgery following radiation failure in squamous cell carcinoma of the supraglottic larynx. Int J Radiat Oncol Biol Phys 1995;32(3):605–09.
Surgical management of irradiation failures in T1-T2 squamous cell carcinoma of the glottic larynx. Anticancer Res 2001;21(6A):4185–88.
Glottic carcinoma: Patterns of failure and salvage treatment after curative radiotherapy in 861 consecutive patients. Radiother Oncol 2002;63(3):257–67.
Factors influencing long-term survival following salvage total laryngectomy after initial radiotherapy or conservative surgery. Head Neck 2006;28(2):99–106.
Salvage surgery following irradiation with different fractionation regimes in the treatment of carcinoma of the laryngo pharynx: Experience gained from a British Institute of Radiology Study. J Laryngol Otol 1992;106(2):147–53.
Quality of life after laryngectomy: Are functional disabilities important? Head Neck 1999;21(4): 319–24.
An investigation into the quality of life of individuals after laryngectomy. Head Neck 2001;23(1):16–24.
Dysphagia following a total laryngectomy: The effect on quality of life, functioning, and psychological well-being. Dysphagia 2009;24(3):314–21.
Long-term quality of life after total laryngectomy. Head Neck 2006;28(4):313–20.