Citation Information :
Biel M, Thankappan K, Henderson B, Rigual N. Photodynamic Therapy for Laryngeal Cancers. Int J Otorhinolaryngol Clin 2010; 2 (3):195-199.
Laryngeal cancer can associated with significant long-term morbidities. Photodynamic (PDT), a minimally invasive treatment that uses light of a specific wavelength to activate a photosensitizing agent in the tumor and its microenvironment, offers a viable alternative treatment for this patient population without permanent treatment related sequelae.
Our focus in this review is to discuss the existing evidence for the utilization PDT in treating laryngeal cancers and to summarize the advantages and limitations of this novel therapy.
Epidemiology and risk factors for head and neck cancer. Semin Oncol Jun 1994;21(3):281–88.
Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol Mar-Apr 1993;14(2):116–21.
Radiotherapy for carcinoma in situ of the true vocal cords. Head and Neck Apr 2002;24(4):390–94.
Management of T1-T2 glottic carcinomas. Cancer May 1 2004;100(9):1786–92.
American Society of Clinical Oncology clinical practice guideline for the use of larynxpreservation strategies in the treatment of laryngeal cancer. J Clin Oncol Aug 1, 2006;24(22):3693–704.
Complete hypopharyngeal obstruction by mucosal adhesions: A complication of intensive chemoradiation for advanced head and neck cancer. Head and neck Aug 2006;28(8):663–70.
Evaluation and management of swallowing dysfunction following chemoradiation for head and neck cancer. Curr Opin Otolaryngol Head Neck Surg Apr 2007;15(2):130–33.
Organ preservation with concurrent chemoradiation for advanced laryngeal cancer: Are we succeeding? Int J Radiat Oncol Biol Phys Feb 1;76(2): 398–402.
Functional outcomes after organ preservation treatment in head and neck cancer: A critical review of the literature. Int J Oral Maxillofac Surg 2006 Jul;35(7):581–87.
Prevention of wound complications following salvage laryngectomy using free vascularized tissue. Head and Neck 2007 May;29(5):425–30.
Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck. N Engl J Med 1990 Sep 20;323(12):795–801.
Retreatment after full course radiotherapy: Is it a viable option? Acta Oncol 1999;38(7):855–62.
Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery. Head and Neck 2003 Nov;25(11):953–59.
Photodynamic therapy. J Natl Cancer Inst. 1998 Jun 17;90(12):889–905.
Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer? Photodiagnosis and photodynamic therapy. 2009 Mar;6(1):3–11.
The role of apoptosis in response to photodynamic therapy: What, where, why, and how. Photochem Photobiol Sci 2002 Jan;1(1):1–21.
The photobiology of photodynamic therapy: Cellular targets and mechanisms. Radiat Res. 1998 Nov;150(5 Suppl):S146–56.
Photodynamic therapy: A review. Drugs and aging. 1999 Jul;15(1):49–68.
Wavelength and light dose dependence in tumour phototherapy with haematoporphyrin derivative. British journal of cancer. 1985 Jul;52(1):43–49.
Mild skin photosensitivity in cancer patients following injection of Photochlor (2-[1-hexyloxyethyl]-2- devinyl pyropheophorbide-A; HPPH) for photodynamic therapy. Cancer chemotherapy and pharmacology. 2006Jan;57(1):40–45.
5-aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett's oesophagus: A randomised trial. Gut 2004 Jun;53(6):785–90.
Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity. Cancer. 1996Oct 1; 78(7):1374–83.
Meso-Tetra (hydroxyphenyl) porphyrins, a new class of potent tumour photosensitisers with favourable selectivity. British Journal of Cancer. Nov 1986;54(5):717–25.
mTHPC mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: A multicenter study of 128 patients. Head and Neck 2004 Mar;26(3):232–40.
[Clinical photodynamic diagnosis and therapy efficiency in oropharyngeal cancer]. Nippon Jibiinkoka Gakkai kaiho. 2009 May;112(5):429–33.
Population pharmacokinetics of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a in cancer patients. Cancer Research 2003 Apr 15;63(8):1806–13.
Use of photodynamic therapy in the treatment of vocal cord carcinoma. Journal of photochemistry and photobiology. 1990 Jul;6(3):291–96.
Photodynamic therapy in head and neck surgery. Journal of photochemistry and photobiology. 1990 Nov;7(2-4):353–58.
PHOTOFRIN-mediated photodynamic therapy for treatment of early stage oral cavity and laryngeal malignancies. Lasers in surgery and medicine. 2001;29(4): 305–13.
Hematoporphyrin photodynamic therapy: Is there truly a future in head and neck oncology? Reflections on a 5- year experience. The Laryngoscope. 1991 Jan;101(1 Pt 1):36–42.
Photodynamic therapy treatment of early oral and laryngeal cancers. Photochemistry and Photobiology. 2007 Sep-Oct;83(5):1063–68.
Photodynamic therapy for head and neck dysplasia and cancer. Archives of otolaryngology—head and neck surgery. 2009 Aug;135(8):784–88.
Clinical study of photodynamic therapy for laryngeal cancer. Nippon Jibiinkoka Gakkai kaiho. 1995 May;98(5):795–804.