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VOLUME 2 , ISSUE 3 ( September-December, 2010 ) > List of Articles


Treatment Decision in the Management of Laryngeal Cancer: An Overview

R Kannan, Sultan A Pradhan

Keywords : Carcinoma larynx,CO2 laser,Concurrent chemoradiation

Citation Information : Kannan R, Pradhan SA. Treatment Decision in the Management of Laryngeal Cancer: An Overview. Int J Otorhinolaryngol Clin 2010; 2 (3):191-194.

DOI: 10.5005/jp-journals-10003-1035

Published Online: 01-04-2011

Copyright Statement:  Copyright © 2010; The Author(s).


A spectrum of treatment plans and surgical procedures are available for management of laryngeal cancer. Transoral laser resection has proved an effective, minimally invasive and functionally satisfactory procedure for management of suitable T1 and T2 glottic cancers, and stage I-III supraglottic cancers. Introduction of chemoradiotherapy has also made great impact on the laryngeal preservation. The treatment of laryngeal cancer should be individualized according to the size and extent of the tumor, the age and physical condition of the patient, and the skill and experience of the surgeon with various treatment modalities and surgical procedures.

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  1. Early glottic cancer: Surgery or radiation therapy? Tumori 1984 Apr 30;70(2): 193–201.
  2. Outcome of open surgical therapy for glottic carcinoma. Ann Otol Rhinol Laryngol. 1993 Oct;102(10):752–55.
  3. Comparsion of surgery and radiotherapy in T1 and T2 glottic carcinomas. Am J Surg. 1991Oct;162(4):337–40.
  4. Results of curative laser microsurgery of laryngeal carcinoma. Am J Otolaryngol. 1993 Mar;14(2):116–21.
  5. Endoscopic laser surgery for laryngeal cancer. Eur Arch Otorhinolaryngol. 2001 Jul;258(5):236–39.
  6. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 2002 Rev 2002;(2):CD002027.
  7. Truths and Myths About Radiotherapy for Verrucous Carcinoma of Larynx. International Journal of Radiation Oncology Biology Physics 73(4):1110–15.
  8. Comparison Among Different Available Surgical Approaches in T1 Glottic cancer. Laryngoscope 2009 Sep;119:1704–08.
  9. Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer. Otolaryngology – Head and Neck Surgery, 2008;138:606–13.
  10. The utility of second-look operation after laser microresection of glottic carcinoma involving the anterior commissure. Laryngoscope 2008;118:1400–04.
  11. Mprphological study of the laryngeal anteriot commissure with regard to the spread of cancer. Act Otolaryngol 1981Jul;92(1-2):167–71.
  12. Endolaryngeal microsurgery at the anterior glottal commissure: controversies and observations. Ann Otol Rhinol Laryngol 2000Apr;109(4):385–92.
  13. Management of early stage laryngeal cancer. Otolaryngol Clin North Am 2008Aug;41(4):757–69.
  14. Fernandez-Vega C. Ramirez. The Gregorio Maranon Hospital experience with vertical partial laryngectomies. Eur Arch Otorhinolaryngol 1999;256:296–98.
  15. Role and limitations of vertical hemilaryngectomy. Can J Otolaryngol 1975;4(3):426–31.
  16. Oncologic outcome of CO2 laser surgery for glottic carcinoma. Chin Med J 2006;119(6):510–13.
  17. Laser surgery for the treatment of larynx carcinoma: indications, techniques, and preliminary results. Ann Otol Rhinol Laryngol. 1992 Feb;101(2 Pt 1):113–18.
  18. Subtotal laryngectomy with cricohyoidoepiglottopexy for the treatment of extended glottic carcinomas. Am J Surg 1991;162:357–61.
  19. Supracricoid laryngectomy with cricohyoidoepiglottopexy: A partial laryngeal procedure for glottic carcinoma. Ann Otol Rhinol Laryngol 1990;99:421–26.
  20. Organ preservation surgery for laryngeal cancer. San Diogo, CA, Singular publishing group 2000.
  21. Head and Neck 2004 March 26(5):442–46.
  22. Endoscopic partial supraglottic laryngectomies: Techniques and results. Otolaryngology—Head and Neck Surgery 2009;141(3):374–81.
  23. Endoscopic CO2 laser treatment of supraglottic carcinoma. Acta Otorhinolaryngol Ital 2003;23:459–66.
  24. Radiation treatment of early stage supraglottic cancer. Ann Otolaryngol Chir Cervicofac 1999;116:66–70.
  25. Initial treatment of the early stage (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol 2000;257:512–16.
  26. Endoscopic laser resection of supraglotic carcinoma. Otolaryngol Head Neck Surg 1997;117:681–87.
  27. Carbon dioxide laser microsurgery for early supraglottic carcinoma. Ann Otol Rhinol Laryngol 1998;107:680–88.
  28. Supraglottic cancer. Laryngoscope 1975;85: 1318–26.
  29. Management of cancer of the supraglottic. Otolaryngol Head Neck Surg 2001;124:195–98.
  30. Update in Head and Neck Cancer: 2008, presented by Massachusetts Eye and Ear Infirmary, 2008;41(19).
  31. Transoral laser surgery for supaglottic cancer. Head Neck 2008 May;30(5):658–66.
  32. Results of an organ conservation protocol in patients with locally advanced laryngeal tumors. Acta Otorrinolaringológica Española 2009;60(3):176–85.
  33. Total laryngectomy and postoperative radiotherapy for T4 laryngeal caner: 4 14 years review. Am J Otolaryngol 2004 Mar;25(2):88–93.
  34. Oncology 1995;9(6): 547–58.
  35. Classification of neck dissection 1993 Dec.
  36. Organ preservation surgery for laryngeal cancer. Head and Neck Oncology 2009; 1:12.
  37. Treatment of head and neck cancers. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds: Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2005;662–732.
  38. Radiation Therapy for Head and Neck Neoplasms. 3rd ed. New York: Wiley-Liss, 1997.
  39. Comprehensive Management of Head and Neck Tumors (2nd ed). Philadelphia, PA: WB Saunders, 1999.
  40. The value of combining radiotherapy with surgery in the treatment of hypopharyngeal and laryngeal cancers. Cancer 1983;51(10): 1819–25.
  41. Tumor response, toxicity, and survival after neoadjuvant organ-preserving chemotherapy for advanced laryngeal carcinoma. The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group. J Clin Oncol 1994;12(8):1592–99.
  42. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer Inst 1996;88(9):583–89.
  43. A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer: Preliminary results. Head Neck 1997; 19(7):567–75.
  44. Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial. J Clin Oncol 2000;18(7):1458–64.
  45. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349(22): 2091–98.
  46. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004;350(19): 1945–52.
  47. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000;355 (9208):949–55.
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