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VOLUME 2 , ISSUE 1 ( January-April, 2010 ) > List of Articles


Transoral Laser Microsurgery for Malignancies of the Upper Aerodigestive Tract

Jason Durel, Jacques Gaudet, Melda Kunduk, Andrew J McWhorter

Keywords : Transoral laser microsurgery,larynx,oral cavity,oropharynx,hypopharynx

Citation Information : Durel J, Gaudet J, Kunduk M, McWhorter AJ. Transoral Laser Microsurgery for Malignancies of the Upper Aerodigestive Tract. Int J Otorhinolaryngol Clin 2010; 2 (1):95-105.

DOI: 10.5005/jp-journals-10003-1022

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2010; The Author(s).


Transoral laser microsurgery (TLM) is an important option in the treatment plan for tumors of the oral cavity, oropharynx, larynx, and hypopharynx. For properly selected patients, TLM provides equivalent oncologic outcomes when compared to traditional therapies, while improving the functional aspects of postoperative speech, voice and swallowing.

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  1. Chapter 1 “History”. Atlas of phonomicrosurgey and other endolaryngeal procedures for benign and malignant disease. San Diego: Singular/Thompson Learning; 2001.
  2. Technique of en bloc laser endoscopic frontolateral laryngectomy for glottic cancer. Laryngoscope 2004;114:175–80.
  3. Microscopic suspension laryngoscopy. Annals of Otology, Rhinology, and Laryngology 1960;69:1134–38.
  4. Intrinsic carcinoma of the larynx with a second report of the cases operated on by suspension and dissection. Transactions of the American Laryngologic Association 1920;42:119–26.
  5. Laser surgery in the larynx: Early clinical experience with continuous CO2 laser. Annals of Otology, Rhinology, and Laryngology 1972;81:791.
  6. Laryngeal Cancer. National cancer database annual review of care 1995.
  7. Experience in endoscopic laser surgery of malignant tumors of the upper aerodigestive tract. Adv Otorhinolaryngol 1988;39:135–44.
  8. CO2 laser treatment of carcinoma of the larynx. Annals of Otology, Rhinology, and Laryngology 1988;67:261–68.
  9. Endoscopic laser surgery of the upper aerodigestive tract. Stuttgart: Thieme; 2000.
  10. Challenging a dogma – Surgery yields superior long-term results for T1 a squamous cell carcinoma of the glottic larynx compared to radiotherapy. European Journal of Surgical Oncology 2008;34:692–98.
  11. Transoral laser microsurgery in carcinomas of the oral cavity, pharynx and larynx. Cancer Control 2002;9(5):379–86.
  12. Endoscopic laser surgery of early glottic cancer: Involvement of the anterior commissure. Head and Neck 2009;31:583–92.
  13. Transoral Laser Surgery for Early Glottic Cancers. Arch Otolaryngol Head Neck Surg. 2003;129:623–25.
  14. Laser surgery for early glottic caner: Impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg 2009;135(4):385–90.
  15. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007;133(12):1198–204.
  16. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091–98.
  17. Carbon dioxide laser microsurgery for early supraglottic carcinoma. Annals of Otology, Rhinology, Laryngology 1998;107:680–88.
  18. Transoral laser surgery for supraglottic cancer. Head and Neck 2008;658–66.
  19. CO2 laser surgery: A larynx preservation alternative for selected hypopharyngeal carcinomas. Head and Neck 2004:953–59.
  20. Organ preserving transoral laser microsurgery for cancer of the hypopharynx. Laryngoscope 2008;118.
  21. Editors:Bailey BJ, Johnson JT, Newlands SD, Calhoun KH, Deskin RW (4th ed). New York: Lippincott Williams and Wilkins 2006.
  22. Transoral laser resection with staged discontinuous neck dissection for oral cavity and oropharynx squamous cell carcinoma. Laryngoscope 1995;105:53–60.
  23. Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg. 2003;129(January):36–43.
  24. Results of radiation therapy in carcinoma of the base of the tongue. The Curie Institute experience with about 166 cases. Cancer 1991;67:1532–38
  25. 97 Squamous cell carcinoma of the base of tongue treated with external-beam radiation therapy: A preferred alternative to surgery. International Journal of Radiation Oncology, Biology, Physics 1999;45(3)Supplement 1:197.
  26. Long-term regional control after radiation therapy and neck dissection for base of tongue carcinoma. International Journal of Radiation Oncology, Biology, Physics 1997;38(5):995–1000.
  27. Discontinuous neck dissection in carcinoma of the oral cavity. Arch Otolaryngol Head Neck Surg 1991;117:1003–06.
  28. Discontinuous vs in-continuity neck dissection in carcinoma of the oral cavity. Experience of two oncologic hospitals. Acta Otorhinolaryngol Ital December 2006;26(6):350–55.
  29. Current concepts and new horizons in conservation laryngeal sugery: An impotant pat of multidisciplinary care. Head and Neck 2009. ePub 8/11/2009.
  30. Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy. Head and Neck 2004;477–84.
  31. Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer. Otolaryngology-Head and Neck Surgery 2008;138:606–13.
  32. Peri- and postoperative complications after laser surgery of tumors of the upper aerodigestive tract. Head and Neck 2007;28:168–72.
  33. Predictive values for aspiration after endoscopic laser resections of malignant tumors of the hypopharynx and larynx. Head and Neck February 2004;26(2);103–10.
  34. Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol 1991;100(8):678–81.
  35. FEESST: A new bedside endoscopic test of the motor and sensory components of swallowing. Ann Otol Rhinol Laryngol 1998;107(5 Pt 1):378–87.
  36. Evaluation and treatment of swallowing disorders. (2nd ed). Austin, TX: Pro-Ed; 1998.
  37. Protocol for swallowing management in patients treated for head and neck cancer. Perspectives on swallowing and swallowing disorders (Dysphagia) June 2006;15:22–26.
  38. Dysphagia following varying degrees of resection for oral cancer. Annals of Otology, Rhinology and Laryngology 1992;101:138–41.
  39. Effect of a tongue holding maneuver on posterior pharyngeal wall movement during deglutition. American Journal of Speech-Language Pathology 1996;5:23–30.
  40. Rehabilitation of swallowing by exercise in tube fed patients with pharyngeal dysphagia secondary to abnormal UES opening. Gastroenterology 2002;122(5):1314–21.
  41. Effects of radiotherapy with or without chemotherapy on tongue strength in patients with oral cancer. Head and Neck 2007;632–37.
  42. Pretreatment, Preoperative Swallowing Exercises May Improve Dysphagia Quality of Life. Laryngoscope June 2006;116:883–86.
  43. Swallowing function after surgery for oral cavity tumors. Perspectives on Swallowing and Swallowing Disorders (Dysphagia) 2001;10:4–9.
  44. Swallowing dysfunction–Preventative and rehabilitation strategies in patients with head and neck cancers treated with surgery, radiotherapy, and chemotherapy: A critical review. International Journal of Radiation Oncology, Biology, Physics 2003;57(5):1219–30.
  45. Carcinoma of the tongue base treated by transoral laser microsurgery, Part I: Untreated tumors, a prospective analysis of oncologic and functional outcomes. Laryngoscope 2006;116(12):2150–55.
  46. Laryngeal adductor reflex and pharyngeal squeeze as predictors of laryngeal penetration and aspiration. Laryngoscope 2002;112(2):338–41.
  47. Phonatory results after laser surgery for glottic carcinoma. Otolaryngol Head Neck Surg 1998;119:418–24.
  48. Prevention of anterior glottic stenosis after transoral microresection of glottic lesions involving the anterior commissure with mitomycin C. Laryngoscope Jun 2005;115(6):1055–59.
  49. Voice and treatment outcome from phonosurgical management of early glottic cancer. Ann Otol Rhinol Laryngol Suppl Dec 2002;190:3–20.
  50. Voice, swallowing and quality of life in patients after transoral surgery for supraglottic carcinoma. Journal of Surgical Oncology 2008;98:184–89.
  51. Swallowing function after endoscopic resection of supraglottic carcinoma with the carbon dioxide laser. Eur Arch Otolaryngol 2001;258:250–54.
  52. Transoral laser surgery for laryngeal cancer: Outcome, complications, prognostic factors in 275 patients. European Journal of Surgical Oncology 2009;35:235–40.
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