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VOLUME 16 , ISSUE 1 ( January-April, 2024 ) > List of Articles


The Vital Role of Nitric Oxide in the Healing of Dental Implant Patients

Nikita Karabale, Pankaj Dhawan, Harsimran Kaur

Keywords : Dental implants, Healing, Nitric oxide, Osseointegration

Citation Information : Karabale N, Dhawan P, Kaur H. The Vital Role of Nitric Oxide in the Healing of Dental Implant Patients. Int J Otorhinolaryngol Clin 2024; 16 (1):64-66.

DOI: 10.5005/jp-journals-10003-1471

License: CC BY-NC 4.0

Published Online: 11-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Background: Nitric oxide, a diatomic free radical activated by phagocytic leukocytes, arginine a catalyzed product that is synthesized by nitric oxide synthases. It is one of the mechanisms which assists in the resolution of inflammation. A review of its effect on healing around dental implants is yet to be studied. Objective: To review the role of nitric oxide on healing around dental implants. Material and methods: A digital search was carried out using Google Scholar, Medline, and PubMed. The most related article was selected for the review. Conclusion: Osseointegration of dental implants is inclined by many factors which affect the bone-implant contact formation process, and it initiates by forming a hematoma, immunomodulation, and angiogenesis following osteogenesis. Nitric oxide shows a biphasic effect on osteoblast and osteoclast activity, which depends on the concentration of nitric oxide and it can be an important factor in achieving successful osseointegration.

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