Introduction: Thyroid surgeries are routinely performed in day-to-day practice. However, parathyroid surgery is a rarely performed surgery that calls upon the highest level of skill and knowledge on the part of the surgeon to perform a complication-free surgery. Parathyroid adenomas are the most common tumors of parathyroid glands leading to hyperparathyroidism. Most of these patients are primarily seen by orthopedic surgeons or physicians and are then referred to the ENT Department for surgery. Aim and objective: To present the clinic-radiological – pathological profile of parathyroid adenoma patients. Materials and methods: Study design: Prospective observation study. Setting: Tertiary Care Centre and Government Medical College. Subjects: Clinico-radiological-pathological profile of 47 consecutive patients who underwent parathyroidectomy for adenomas during a 5-year period from 2016 to 2020 in our institute which is a Tertiary Care Hospital and Medical College excluding patients operated for parathyroid carcinoma. Results: Findings were suggestive of adenomas in left inferior parathyroid (18), right inferior parathyroid (11), left superior parathyroid (9), right superior parathyroid (7) and in one patient there were 2 parathyroid adenomas. Conclusion: We conclude that accurate diagnosis and thorough knowledge of anatomy is the key to carry out a successful parathyroid surgery.