An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 15 , ISSUE 3 ( September-December, 2023 ) > List of Articles

Original Article

Frequency Selectivity of the Auditory System in Females with Anemia: An Indian Scenario

Tejaswini Honnegowda, Avinash Krishnamurthy, Nagarathna Hosalli Kumaraswamy, Ashwini Guttedar

Keywords : Anemia, Characteristic frequency, Frequency resolution, Frequency selectivity, Psychophysical tuning curves, Q10

Citation Information : Honnegowda T, Krishnamurthy A, Kumaraswamy NH, Guttedar A. Frequency Selectivity of the Auditory System in Females with Anemia: An Indian Scenario. Int J Otorhinolaryngol Clin 2023; 15 (3):95-98.

DOI: 10.5005/jp-journals-10003-1448

License: CC BY-NC 4.0

Published Online: 09-01-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Background: Frequency selectivity is one of the processes of the auditory system to evaluate the individual components of a complex sound. Frequency selectivity is one of the most critical factors that determine speech perception, particularly in the presence of competing signals. Anemia is a clinical scenario in which there is a decreased level of red blood cells. Evidence suggests that anemia is more prevalent in females than males and could be an early indicator of hearing loss. The objective of the study is to compare the frequency selective abilities in normal hearing females with and without anemia. Materials and methods: A total of 30 females in the age range of 20–30 years with hearing sensitivity within normal limits participated, in which 15 females were anemic, and 15 females were non-anemic. A total of 60 ears were evaluated. The auditory system frequency selectivity was measured through psychophysical tuning curves (PTCs) at different characteristic frequencies (500, 1000, 2000, 3000, and 4000 Hz), and Q10 values for the same were calculated at different characteristic frequencies. Results: In this study, there was reduced Q10 value for females with anemia at all the characteristic frequencies compared to females without anemia, indicating poor frequency resolution in females with anemia. Conclusion: The outcomes of the present study will help in understanding the changing frequency selectivity of the auditory system in individuals with anemia.

  1. Glasberg BR, Moore BCJ. Auditory filter shapes in subjects with unilateral and bilateral cochlear impairments. J Acoust Soc Am 1986;79(4):1020–1033. DOI: 10.1121/1.393374.
  2. Hicks ML, Bacon SP. Effects of aspirin on psychophysical measures of frequency selectivity, two-tone suppression, and growth of masking. J Acoust Soc Am 1999;106(3 Pt 1):1436–1451. DOI: 10.1121/1.42714.
  3. Horst JW. Frequency discrimination of complex signals, frequency selectivity, and speech perception in hearing-impaired subjects. J Acoust Soc Am 1987;82(3):874–885. DOI: 10.1121/1.395286.
  4. Moore BC. Basic auditory processes involved in the analysis of speech sounds. Philos Trans R Soc Lond B Biol Sci 2008;363(1493):947–963. DOI: 10.1098/rstb.2007.2152.
  5. Pickles JO. Frequency threshold curves and simultaneous masking functions in high-threshold, broadly-tuned, fibres of the guinea pig auditory nerve. Hearing Res 1984;16(1): 91–99. DOI: 10.1016/0378-5955(84)90027-3.
  6. Palmer AR. Physiology of the Cochlear Nerve and Cochlear Nucleus. In: Hearing, Haggard MP and Evans EF, editors. Edinburgh: Churchill Livingstone, 1987; pp. 838–855.
  7. Sun AH, Xiao SZ, Li BS, et al. Iron deficiency and hearing loss. Experimental study in growing rats. ORL J Otorhinolaryngol Relat Spec 1987;49(3):118–122. DOI: 10.1159/000275920.
  8. Sun AH, Wang ZM, Xiao SZ, et al. Sudden sensorineural hearing loss induced by experimental iron deficiency in rats. ORL J Otorhinolaryngol Relat Spec 1992;54(5):246–250. DOI: 10.1159/000276307.
  9. Chang YL, Hung SH, Ling W, et al. Association between ischemic stroke and iron-deficiency anemia: A population-based study. PLoS One 2013;8(12):e82952. DOI: 10.1371/journal.pone.0082952.
  10. Tagoe T, Barker M, Jones A, et al. Auditory nerve perinodal dysmyelination in noise-induced hearing loss. J Neurosci 2014;34(7): 2684–2688. DOI: 10.1523/JNEUROSCI.3977-13.2014.
  11. Chung SD, Chen PY, Lin HC, et al. Sudden sensorineural hearing loss associated with iron-deficiency anemia: A population-based study. JAMA Otolaryngol Head Neck Surg 2014;140(5):417–422. DOI: 10.1001/jamaoto.2014.75.
  12. Shi X. Physiopathology of the cochlear microcirculation. Hear Res 2011;282(1–2):10–24. DOI: 10.1016/j.heares.2011.08.006.
  13. Chung JH, Lee SH, Park CW et al. Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss. Laryngoscope 2016;126(8):1918–1922. DOI: 10.1002/lary.25853.
  14. Zhang C. Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell 2014;5(10):750–760. DOI: 10.1007/s13238-014-0083-7.
  15. Badaracco ME, Ortiz EH, Soto EF, et al. Effect of transferrin on hypomyelination induced by iron deficiency. J Neurosci Res 2008;86(12):2663–2673. DOI: 10.1002/jnr.21709.
  16. Souza P, Hoover E. The physiologic and psychophysical consequences of severe-to-profound hearing loss. Semin Hear 2018;39(4):349–363. DOI: 10.1055/s-0038-1670698.
  17. Verheij E, Oomen KPQ, Smetsers SE, et al. Hearing loss and speech perception in noise difficulties in Fanconi anemia. Laryngoscope 2017;127(10):2358–2361. DOI: 10.1002/lary.26480.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.