From open excision of the pouch to the flexible endoscopy and division of cricopharyngeus, there are multiple options for the division of wall between esophagus and Zenker's diverticulum (ZD) depending on its size, availability of resources, and their side effects. Hereby, we report a case of 43-year-old female who presented with complaints of progressive dysphagia, regurgitation of food particles, gurgling sound on taking liquids, and dyspnea on lying down. Barium swallow and esophagogastroduodenoscopy helped in diagnosing it to be ZD. One-stage endoscopic diverticulotomy using stapler and harmonic scalpel leads to significant improvement in symptoms with no complaints even after 1 year postsurgery. Thereby, a combination of stapler and harmonic scalpel can be used for one-stage endoscopic diverticulotomy without any major complication making it a good alternative to modalities like LASER. Key messages: A combination of stapler and harmonic scalpel can be used for one-stage endoscopic diverticulotomy for ZD without any major complication making it a good alternative to modalities like LASER.