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VOLUME 13 , ISSUE 3 ( September-December, 2021 ) > List of Articles


Recurrent Laryngeal Papillomatosis: A Laser CO2 Surgery and Bevacizumab Intralesional Injection as Adjuvant Therapy

Cosimo Galletti, Galletti Bruno, Francesco Ciodaro, Francesco Galletti

Keywords : Airway obstruction, Bevacizumab, HPV, Laryngology, Laser, Oncology, Surgery

Citation Information : Galletti C, Bruno G, Ciodaro F, Galletti F. Recurrent Laryngeal Papillomatosis: A Laser CO2 Surgery and Bevacizumab Intralesional Injection as Adjuvant Therapy. Int J Otorhinolaryngol Clin 2021; 13 (3):126-128.

DOI: 10.5005/jp-journals-10003-1386

License: CC BY-NC 4.0

Published Online: 21-04-2022

Copyright Statement:  Copyright © 2021; The Author(s).


We present a case of recurrent respiratory papillomatosis (RRP) transformed in a lobular intraepithelial neoplasia LIN 2 vocal fold lesion treated with a microdirect laryngoscope with 10,600-nm laser CO2, in addition, adjuvant therapy is performed which consists of an intralesional bevacizumab injection on surgical site. Adjuvant therapy involves a cycle of four intralesional bevacizumab injections. The RRP is characterized as a long-life condition of the respiratory epithelium caused by the human papilloma virus (HPV), HPV 6 and 11 genotypes in most of all cases. Airway obstruction or voice correlated symptoms are the most common way of presentation, which can be variated from a low–mild form to severe which can represent, in rare cases, a situation that requires prompt treatment. This study aims to evaluate the efficacy and safety of the use of intralesional bevacizumab as adjuvant therapy in the treatment of RRP.

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