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VOLUME 13 , ISSUE 2 ( May-August, 2021 ) > List of Articles


Isolated Primary Laryngeal Amyloidosis: A Case Series of a Rare Presentation of Change in Voice

Anmol Wadhwa, Bhavika Verma, Yogesh G Dabholkar

Keywords : Amyloidosis, Hoarseness of voice, Laryngeal

Citation Information : Wadhwa A, Verma B, Dabholkar YG. Isolated Primary Laryngeal Amyloidosis: A Case Series of a Rare Presentation of Change in Voice. Int J Otorhinolaryngol Clin 2021; 13 (2):73-75.

DOI: 10.5005/jp-journals-10003-1384

License: CC BY-NC 4.0

Published Online: 20-11-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Introduction: Amyloidosis is a benign disease which comprises heterogeneous group of disorders that are characterized by accumulation of amyloid proteins in various body organs. Of the various types, laryngeal amyloidosis is a rare disease of unknown etiology. Case report: We report three cases of isolated primary laryngeal amyloidosis who presented with hoarseness of voice as their chief complaint. A diagnosis was made based on histopathology after a thorough clinical and laboratory workup, and the patients responded well to the surgical excision of the growth and to a combination therapy of oral corticosteroids and bortezomib. Conclusion: Laryngeal amyloidosis, though a rare disease, is a common site for isolated amyloid deposits to occur in head and neck regions, and its diagnosis requires a high index of suspicion as well as thorough workup to exclude systemic involvement.

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