Isolated Primary Laryngeal Amyloidosis: A Case Series of a Rare Presentation of Change in Voice
Anmol Wadhwa, Bhavika Verma, Yogesh G Dabholkar
Keywords :
Amyloidosis, Hoarseness of voice, Laryngeal
Citation Information :
Wadhwa A, Verma B, Dabholkar YG. Isolated Primary Laryngeal Amyloidosis: A Case Series of a Rare Presentation of Change in Voice. Int J Otorhinolaryngol Clin 2021; 13 (2):73-75.
Introduction: Amyloidosis is a benign disease which comprises heterogeneous group of disorders that are characterized by accumulation of amyloid proteins in various body organs. Of the various types, laryngeal amyloidosis is a rare disease of unknown etiology.
Case report: We report three cases of isolated primary laryngeal amyloidosis who presented with hoarseness of voice as their chief complaint. A diagnosis was made based on histopathology after a thorough clinical and laboratory workup, and the patients responded well to the surgical excision of the growth and to a combination therapy of oral corticosteroids and bortezomib.
Conclusion: Laryngeal amyloidosis, though a rare disease, is a common site for isolated amyloid deposits to occur in head and neck regions, and its diagnosis requires a high index of suspicion as well as thorough workup to exclude systemic involvement.
Saleem T, Fatima S, Ghaffar S, et al. Two cases of primary laryngeal amyloidosis. J Pak Med Assoc 2009 Nov;59(11):789–91. PMID: 20361683.
Alaani A, Warfield AT, Pracy JP. Management of laryngeal amyloidosis. J Laryngol Otol 2004;118(4):279–283. DOI: 10.1258/002221504323012021.
Lachman HJ, Hawkins PN. Amyloidosis of the lung. Chron Resp Dis 2006;3(4):203–214. DOI: 10.1177/1479972306070066.
Sonkhya N, Mittal P, Sonkhya D, et al. Localized laryngeal amyloidosis: a case report and review of literature. Global Adv Res J Med Med Sci 2012;1(3):45–48.
Thompson LD, Derringer GA, Wenig BM. Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Mod Pathol 2000;13(5):528–535. DOI: 10.1038/modpathol.3880092.
Lewis JE, Olsen KD, Kurtin PJ, et al. Laryngeal amyloidosis: a clinicopathologic and immunohistochemical review. Otolaryngol Head Neck Surg 1992;106(4):372–377. DOI: 10.1177/019459989210600410.
Siddachari RC, Chankar DA, Pramesh CS, et al. Laryngeal amyloidosis. J Otolaryngol 2005;34(1):60–63. DOI: 10.2310/7070.2005.03131.
Wadhwa A, Dabholkar YG, Bhatt BV et.al. Primary diffuse laryngeal amyloidosis, a rare cause of hoarseness of voice. Int J Health Sci Res 2019;9(11):111–114.
Jiang F, Chen J, Liu H, et al. The effect and safety of bortezomib in the treatment of AL amyloidosis: a systematic review and meta-analysis. Indian J Hematol Blood Transfus 2018;34(2):216–226. DOI: 10.1007/s12288-018-0937-x.
