Introduction: Amyloidosis is a benign disease which comprises heterogeneous group of disorders that are characterized by accumulation of amyloid proteins in various body organs. Of the various types, laryngeal amyloidosis is a rare disease of unknown etiology.
Case report: We report three cases of isolated primary laryngeal amyloidosis who presented with hoarseness of voice as their chief complaint. A diagnosis was made based on histopathology after a thorough clinical and laboratory workup, and the patients responded well to the surgical excision of the growth and to a combination therapy of oral corticosteroids and bortezomib.
Conclusion: Laryngeal amyloidosis, though a rare disease, is a common site for isolated amyloid deposits to occur in head and neck regions, and its diagnosis requires a high index of suspicion as well as thorough workup to exclude systemic involvement.
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