Non-Hodgkin's lymphoma especially the diffuse large B-cell lymphoma variety accounts for a considerable fraction of lymphomas. However, their de novo occurrence in the Waldeyer's ring is rare. The independent origin of this condition as a large unilateral tonsillar swelling makes it an interesting presentation in clinical practice. Here, we present such a case with the few known aspects of this condition.
Laskar S, Bahl G, Muckaden MA, et al. Primary diffuse large B-cell lymphoma of the tonsil: is a higher radiotherapy dose required? Cancer 2007;110(4):816–823. DOI: 10.1002/cncr.22841.
Guevara-Canales JO, Morales-Vadillo R, de Faria PE, et al. Systematic review of lymphoma in oral cavity and maxillofacial region. Acta Odontol Latinoam 2011;24(3):245–250. PMID-22550817.
Jacobs C, Hoppe RT. Non-Hodgkin's lymphoma of head and neck extranodal sites. Int J Radiat Oncol Biol Phys 1985;11(2):357–364. DOI: 10.1016/0360-3016(85)90158-0.
Jacobs C, Weiss L, Hoppe RT. The management of extranodal head and neck lymphomas. Arch Otolaryngol Head Neck Surg 1986;112(6):654–658. DOI: 10.1001/archotol.1986.03780060066010.
Hemalatha AL, Sushma HM, Indira CS, et al. Diffuse large B-cell lymphoma arising de novo in unilateral tonsil. National J Lab Med 2014;3(4):12–14. DOI: NJLM/2014/10113:2020.
Rai B, Astekar MS, Manjunatha BS, et al. Diffuse large B cell lymphoma of hard palate: a case report with literature review. J Exp Ther Oncol 2017;11(2):101–105. PMID-28976132.
Kristin EH, Kaaren KR. Diffuse large B-cell lymphoma. Arch Pathol Lab Med 2008;132(1):118–124. DOI: 10.5858/2008-132-118-DLBL.
de Leval L, Harris NL. Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance. Histopathology 2003;43(6):509–528. DOI: 10.1111/j.1365-2559.2003.01758.x.
Mohammadianpanah M, Daneshbod Y, Ramzi M, et al. Primary tonsillar lymphomas according to the new World Health Organization classification: to report 87 cases and literature review and analysis. Ann Hematol 2010;89(10):993–1001. DOI: 10.1007/s00277-010-0970-9.
Qin Y, Shi YK, He XH, et al. Clinical features of 89 patients with primary non Hodgkin's lymphoma of the tonsil. Ai Zheng 2006;25(4):481–485. PMID-16613685.
Gao Y, Li Y, Yuan Z, et al. Prognostic factors in patients with primary non Hodgkin's lymphoma of the tonsil. Zhonghua Zhong Liu Za Zhi 2002;24(5):483–485. PMID-12485504.
Endo S, Kida A, Sawada U, et al. Clinical analysis of malignant lymphomas of tonsil. Acta Otolaryngol Suppl 1996;523:263–266. PMID-9082802.
Lopez-Guillermo A, Colomo L, Jimenez M, et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol 2005;23(12):2797–2804. DOI: 10.1200/JCO.2005.07.155.