An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 12 , ISSUE 2 ( May-August, 2020 ) > List of Articles

RESEARCH ARTICLE

Postoperative Hypothyroidism after Lobectomy for Colloid Goiter

Manzoor A Latoo, Aleena S Jallu, Qurat-ul-ain Batool

Keywords : Hypothyroidism, Lobectomy, Thyroid,Colloid goiter

Citation Information : Latoo MA, Jallu AS, Batool Q. Postoperative Hypothyroidism after Lobectomy for Colloid Goiter. Int J Otorhinolaryngol Clin 2020; 12 (2):21-24.

DOI: 10.5005/jp-journals-10003-1354

License: CC BY-NC 4.0

Published Online: 03-03-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and objective: The study aimed to evaluate the incidence and associated risk factors for the development of hypothyroidism in patients who underwent lobectomy for colloid goiter. Materials and methods: The study included 50 patients, out of which postoperative hypothyroidism was observed in 18 patients, with an overall incidence of 36%. Hypothyroidism was diagnosed in 90% of patients within 9 months after the surgery. The preoperative TSH levels were directly proportional to the postoperative TSH levels and were confirmed as independent risk factors for the development of hypothyroidism. Discussion and conclusion: The incidence of postoperative hypothyroidism after lobectomy is quite significant and cannot be ignored. Elevated preoperative TSH levels are associated with an increased risk. A long follow-up period is required to find the true incidence of postoperative hypothyroidism and identify those having subclinical hypothyroidism.


PDF Share
  1. Shahulhameed S, Anjali S, Poulose PK. Prevalence of thyroid auto antibodies in young asymptomatic females: a pilot study. Thyroid Res Pract 2012;9(1):9–11. DOI: 10.4103/0973-0354.92389.
  2. Verloop H, Louwerens M, Schoones JW, et al. Risk of hypothyroidism following hemithyroidectomy: systematic review and meta-analysis of prognostic studies. J Clin Endocrinol Metab 2012;97(7):2243–2255. DOI: 10.1210/jc.2012-1063.
  3. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid 2016;26(1):1–133. DOI: 10.1089/thy.2015.0020.
  4. Koh YW, Lee SW, Choi EC, et al. Prediction of hypothyroidism after hemithyroidectomy: A biochemical and pathological analysis. Eur Arch Otorhinolaryngol 2008;265(4):453–457. DOI: 10.1007/s00405-007-0513-8.
  5. Su SY, Grodski S, Serpell JW. Hypothyroidism following hemithyroidectomy: A retrospective review. Ann Surg 2009;250(6):991–994. DOI: 10.1097/SLA.0b013e3181ae5426.
  6. Piper HG, Bugis SP, Wilkins GE, et al. Detecting and defining hypothyroidism after hemithyroidectomy. Am J Surg 2005;189(5):587–591; discussion 591. DOI: 10.1016/j.amjsurg.2005.01.038.
  7. Spanheimer PM, Sugg SL, Lal G, et al. Surveillance and intervention after thyroid lobectomy. Ann Surg Oncol 2011;18(6):1729–1733. DOI: 10.1245/s10434-010-1544-8.
  8. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001;344(7):501–509. DOI: 10.1056/NEJM200102153440707.
  9. Turner MR, Camacho X, Fischer HD, et al. Levothyroxine dose and risk of fractures in older adults: Nested case-control study. BMJ 2011;342:d2238. DOI: 10.1136/bmj.d2238.
  10. Col NF, Surks MI, Daniels GH. Subclinical thyroid disease: clinical applications. JAMA 2004;291(2):239–243. DOI: 10.1001/jama.291.2.239.
  11. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. JAMA 2004;291(2):228–238. DOI: 10.1001/jama.291.2.228.
  12. Ross DS. Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. Endocrinol Metab Clin North Am 2001;30(2):245–264, vii. DOI: 10.1016/s0889-8529(05)70186-9.
  13. Parle JV, Franklyn JA, Cross KW, et al. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf) 1991;34(1):77–83. DOI: 10.1111/j.1365-2265.1991.tb01739.x.
  14. Sawin CT. Subclinical hypothyroidism in older persons. Clin Geriatr Med 1995;11(2):231–238.
  15. Cooper DS, Biondi B. Subclinical thyroid disease. Lancet 2012;379(9821):1142–1154. DOI: 10.1016/S0140-6736(11)60276-6.
  16. Ahn D, Sohn JH, Jeon JH. Hypothyroidism following hemithyroidectomy: incidence, risk factors, and clinical characteristics. J Clin Endocrinol Metab 2016;101(4):1429–1436. DOI: 10.1210/jc.2015-3997.
  17. Johner A, Griffith OL, Walker B, et al. Detection and management of hypothyroidism following thyroid lobectomy: evaluation of a clinical algorithm. Ann Surg Oncol 2011;18(9):2548–2554. DOI: 10.1245/s10434-011-1627-1.
  18. Chu KK, Lang BH. Clinicopathologic predictors for early and late biochemical hypothyroidism after hemithyroidectomy. Am J Surg 2012;203(4):461–466. DOI: 10.1016/j.amjsurg.2011.03.004.
  19. McHenry CR, Slusarczyk SJ. Hypothyroidism following hemithyroidectomy: incidence, risk factors, and management. Surgery 2000;128(6):994–998. DOI: 10.1067/msy.2000.110242.
  20. Miller FR, Paulson D, Prihoda TJ, et al. Risk factors for the development of hypothyroidism after hemithyroidectomy. Arch Otolaryngol Head Neck Surg 2006; 132(1):36–38. DOI: 10.1001/archotol.132.1.36.
  21. Berglund J, Bondeson L, Christensen SB, et al. The influence of different degrees of chronic lymphocytic thyroiditis on thyroid function after surgery for benign, non-toxic goiter. Eur J Surg 1991;157(4):257–260.
  22. Capezzuto E, Carlini M, Balsanelli M, et al. Post-surgical hypothyroidism: lymphocyte infiltration and antithyroglobulin antibodies as markers in 73 cases studied by us [in Italian]. Minerva Chir 1987;42(4):323–326.
  23. Said M, Chiu V, Haigh PI. Hypothyroidism after hemithyroidectomy. World J Surg 2013;37(12):2839–2844. DOI: 10.1007/s00268-013-2201-8.
  24. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87(2):489–499. DOI: 10.1210/jcem.87.2.8182.
  25. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008;29(1):76–131. DOI: 10.1210/er.2006-0043.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.