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VOLUME 11 , ISSUE 3 ( September-December, 2019 ) > List of Articles


Microbiome Profile in Chronic Rhinosinusitis with and without Polyps of Makassar, Indonesia

Azmi Mir\'ah Zakiah, Muhammad Fadjar Perkasa, Amelia Dian Utami, Riskiana Djamin, Burhanuddin Bahar, Firdaus Hamid, Abdul Qadar Punagi

Keywords : Chronic rhinosinusitis, Microbiome, Nasal polyps

Citation Information : Zakiah AM, Perkasa MF, Utami AD, Djamin R, Bahar B, Hamid F, Punagi AQ. Microbiome Profile in Chronic Rhinosinusitis with and without Polyps of Makassar, Indonesia. Int J Otorhinolaryngol Clin 2019; 11 (3):55-63.

DOI: 10.5005/jp-journals-10003-1337

License: CC BY-NC 4.0

Published Online: 02-03-2021

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Background: Chronic rhinosinusitis (CRS) is a prevalent health problem that results in a large costly burden in society is often associated with the role of the microbiome that seems to maintain a healthy state and stability of the sinonasal environment often viewed as a symbiotic system. Aim and objective: This study aimed to identify a microbiome profile in chronic rhinosinusitis with and without nasal polyps of Indonesian population. Materials and methods: This study was conducted using the case-control technique on 20 patients divided into two groups. The first group is CRS without nasal polyps consisted of 10 patients and the second group is CRS with nasal polyps consisted of 10 patients. All of the samples were examined by next-generation sequencing techniques. Results: Microbes were detected in all samples. Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, Fusobacteria, and Proteobacteria were the dominant phylum in both groups with a variable number of percentages. Conclusion: This study highlights alteration of the commensal microbe may lead to dysbiosis conditions of the sinonasal environment.

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  1. In: Chan Y, Goddard J, ed. K. J. Lee's Essential Otolaryngology Head and Neck Surgery. 11th ed., New York: McGraw Hill; 2016. pp. 491–509.
  2. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologist. Rhinology 2012;50(1):1–12.
  3. ICON: chronic rhinosinusitis. World Allergy Organ J 2014;25(7):25. DOI: 10.1186/1939-4551-7-25.
  4. A systematic review of the sinonasal microbiome in chronic rhinosinusitis. Am J Rhinol Allergy 2016;30(3):162–166. DOI: 10.2500/ajra.2016.30.4320.
  5. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol 2015;136(6):1442–1453. DOI: 10.1016/j.jaci.2015.10.009.
  6. The microbiome and chronic rhinosinusitis. World J Otorhinolaryngol Head Neck Surg 2018;4(3):216–221. DOI: 10.1016/j.wjorl.2018.08.004.
  7. The microbiome in chronic inflammatory airway disease: a threatened species. S Afr Med J 2016;106(8):779–781. DOI: 10.7196/SAMJ.2016.v106i8.11159.
  8. A comprehensive review of the nasal microbiome in chronis rhinosinustis (CRS). Clin Exp Allergy 2016;46(1):21–41. DOI: 10.1111/cea.12666.
  9. The sinonasal bacterial microbiome in health and disease. Curr Opin Otolaryngol Head Neck Surg 2016;24(1):20–25. DOI: 10.1097/MOO.0000000000000221.
  10. Chronic rhinosinusitis: potential role of microbial dysbiosis and recommendations for sampling sites. Front Cell Infect Microbiol 2018;8:57. DOI: 10.3389/fcimb.2018.00057.
  11. The microbiome of upper airways: focus on chronic rhinosinusitis. World Allergy Organ J 2014;8(3):3.
  12. Quantitative and qualitative betadiversity measures lead to different insights into factors that structure microbial communities. Appl Environ Microbiol 2007;73(5):1576–1585. DOI: 10.1128/AEM.01996-06.
  13. Microbiome and cultured based analysis of chronic rhinosinusitis compared to healthy sinus mucosa. Front Microbiol 2018;9:643. DOI: 10.3389/fmicb.2018.00643.
  14. The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 2013;13:210. DOI: 10.1186/1471-2334-13-210.
  15. The bacterial microbiome in chronic rhinosinusitis: richness, diversity, post operative changes, and patient outcomes. Am J Rhinol Allergy 2016;30(1):37–43. DOI: 10.2500/ajra.2016.30.4261.
  16. Evidence of microbiota dysbiosis in chronis rhinosinusitis. Int Forum Allergy Rhinol 2016;7(3):230–239. DOI: 10.1002/alr.21871.
  17. The microbime of the middle meatus in healthy adults. Plos One Journal 2013;8(12):1–10. DOI: 10.1371/journal.pone.0085507.
  18. Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome. J Allergy Clin Immunol 2015;136(2):334–42.e1. DOI: 10.1016/j.jaci.2015.02.008.
  19. Contrasting the microbiome from healthy volunteers and patients with chronic rhinosinusitis. JAMA Otolaryngology Head and Neck Surgery 2013;139(12):1328–1338. DOI: 10.1001/jamaoto.2013.5465.
  20. Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environ Microbiol 2017;19(1):381–392. DOI: 10.1111/1462-2920.13632.
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