Aims and objectives: To determine the effect of early physiotherapy in endotracheal intubation-induced temporomandibular joint dysfunction (TMD) and to compare the effect of early physiotherapy interventions and conventional treatment (CT) in TMD in endotracheal extubated patients. Meterials and methods: An experimental study was carried out in 40 endotracheal extubated (ETE) subjects diagnosed with TMD. The subjects were randomly allocated to group I as an experimental group receiving early physiotherapy and group II as a conventional group receiving routine treatment for 14 days. The outcome measures were used the American Academy of Orofacial Pain (AAOP) Questionnaire, visual Analog scale (VAS), physical assessment tool, range of motion (ROM) of TMJ, tenderness over orofacial muscles. Results: The results obtained show that both the groups showed significant improvement in the outcome variables and therefore aids with early correction of dysfunction. Within group analysis showed statistically more significant improvement in all outcome measures for group I. VAS (p < 0.0001), ROM for all four motions (p < 0.0001), auscultation test = 95% improvement, provocation test = 95% improvement, tenderness = 95%. However only, AAOP questionnaire was not significant for group II (p value > 0.001). Conclusion: We found that those early physiotherapy interventions showed significant improvement in the outcome variables concluding that it improves TMJ mobility and reduces pain. It can be further concluded that conventional treatment can be more efficacious if combined with early physiotherapy interventions.