An International Journal of Otorhinolaryngology Clinics

Register      Login

VOLUME 10 , ISSUE 1 ( January-April, 2018 ) > List of Articles

ORIGINAL ARTICLE

Significance of Tissue Eosinophil in Unilateral Nasal Polyp

UP Santosh, KB Sunil Kumar, M Divyashree, DR Aravind

Keywords : Allergy, Fisher's exact test, Inflammation.

Citation Information : Santosh U, Kumar KS, Divyashree M, Aravind D. Significance of Tissue Eosinophil in Unilateral Nasal Polyp. Int J Otorhinolaryngol Clin 2018; 10 (1):1-3.

DOI: 10.5005/jp-journals-10003-1279

License: CC BY-NC 3.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Introduction: Nasal polyp is an inflammatory condition of unknown etiology with a prevalence rate of about 4%. Unilateral nasal polyp is common in the ear, nose, and throat (ENT) practice and publications in the literature in this regard are few. Aim: The aim of this study was histological analysis of eosinophil cells in unilateral nasal polyp and to correlate its relationship of allergic etiology with unilateral nasal polyp. Materials and methods: The study conducted was a retrospective study where 70 patients diagnosed as unilateral nasal polyp were analyzed with their histopathology reports. It included patients of either sex with age between 6 and 65 years. All these patients had undergone surgery and polyp specimen was sent for histopathological examination. The patients were grouped as per their histopathological diagnosis as inflammatory polyp with tissue eosinophil and inflammatory polyp without tissue eosinophil and were compared. Tissue eosinophil grading was done according to Shioda and Mishima system. Data were analyzed and a conclusion was drawn. Results: In total 70 patients (100%) of unilateral nasal polyp, 33 patients (47%) showed presence of tissue eosinophil and 37 patients (53%) showed absence of tissue eosinophil in histopathological examination. Out of 33 patients with tissue eosinophil, 16 patients (48.5%) showed significant tissue eosinophil with p < 0.0000. Conclusion: Since the p-value is significant in our study, otorhinolaryngologists should consider allergy as an etiological factor in the management of unilateral nasal polyp.


PDF Share
  1. Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999 Aug;28(4):717-722.
  2. Santosh UP, Sunil Kumar KB, Pandurangi AS. Clinicopathological correlation between peripheral blood eosinophilia and inferior turbinate tissue eosinophils. AIJOC 2015;1:6-8.
  3. Yuca K, Bayram I, Kiroðlu AF, Etlik O, Cankaya H, Sakin F, Kiriþ M. Evaluation and treatment of antrochoanal polyps. J Otolaryngol 2006 Dec;35(6):420-423.
  4. Larsen K, Tos M. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol 2002 Mar;122(2):179-182.
  5. Gleeson, M; Browning, GG; Burton, MJ, Clarke, R; Hibbert, J; Jones, NS; Lund, VJ; Luxon, LM; Watkinson, JC. Scott Brown's otorhinolaryngology, head and neck surgery. 7th ed. Vol. 2. In: Mygind N, Lund VJ. Boca Raton (FL): CRC Press; 2008. Chapter 121, Nasal polyposis; pp. 1549-1559
  6. Jeong WJ, Lee CH, Cho SH, Rhee CS. Eosinophilic allergic polyp: a clinically oriented concept of nasal polyp. Otolaryngol Head Neck Surg 2011 Feb;144(2):241-246.
  7. Zhang G, Zhang J, Shi W, Sun P, Lin P. Relationship between allergic factors and eosinophilic nasal polyps. J Clin Otorhinolaryngol Head Neck Surg 2015 Jun;29(12):1098-1100.
  8. Fan GK, Wang H, Takenaka H. Eosinophil infiltration and activation in nasal polyposis. Acta Otolaryngol 2007 May;127(5):521-526.
  9. Jankowski R. Eosinophils in the pathophysiology of nasal polyposis. Acta Otolaryngol 1996 Mar;116(2):160-163.
  10. Goldberg, B. Clinical tuberculosis. Philadelphia (PA): FA Davis Company Publishers; 1946.
  11. Sharan R. Primary tuberculosis of the nose. Practitioner 1981 Oct; 225(1360):1506-1507.
  12. Agulles Formes MJ, Agut Fuster MA, Grau Mario E, Alario EG. Primary nasal tuberculosis: a forgotten disease? Acta Otolaryngol Esp 2004;55:240-243.
  13. Hyun DW, Ryu JH, Kim YS, Kim KB, Kim WS, Kim CH, Yoon JH. Treatment outcomes of juvenile nasopharyngeal angiofibroma according to surgical approach. Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):69-73.
  14. Hsieh ST, Guo YC, Tsai TL, Chen WY, Huang JL. Angiofibroma of the hypopharynx. J Chin Med Assoc 2004 Jul;67(7): 373-375.
  15. Madana J, Yolmo D, Gopalkrishnan S, Saxena S. Extranasopharyngeal angiofibroma of the cartilaginous nasal septum: possible origin from ectopic tissue trapped during septal development. Internet J Otorhinolaryngol 2012;14(1):1-5.
  16. Dobratz EJ, Tran V, Hilger PA. Comparison of techniques used to support the nasal tip and their long-term effects on tip position. Arch Facial Plast Surg 2010 May-Jun;12(3):172-179.
  17. Friedman O, Koch CA, Smith WR. Functional support of the nasal tip. Facial Plast Surg 2012 Apr;28(2):225-230.
  18. Mohebbi A, Jahandideh H, Faham Z, Jafari M. Defining the best nasal tip projection among Iranian women. Plast Surg Int 2016;2016:8549276.
  19. Bhattacharyya N. Bacterial infection in chronic rhinosinusitis: a controlled paired analysis. Am J Rhinol 2005 Nov- Dec;19(6):544-548.
  20. Boase S, Foreman A, Cleland E, Tan L, Melton-Kroft R, Pant H, Hu FZ, Ehrlich GD, Wormald PJ. The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 2013 May;13:210.
  21. Mantovani K, Bisanha AA, Demarco RC, Tamashiro E, Martinez R, Anselmo-Lima WT. Maxillary sinuses microbiology from patients with chronic rhinosinusitis. Braz J Otorhinolaryngol 2010 Sep-Oct;76(5):548-551.
  22. Brook I, Gober AE. Recovery of potential pathogens in the nasopharynx of healthy and otitis media-prone children and their smoking and nonsmoking parents. Ann Otol Rhinol Laryngol 2008 Oct;117(10):727-730.
  23. Wu J, Peters BA, Dominianni C, Zhang Y, Pei Z, Yang L, Ma Y, Purdue MP, Jacobs EJ, Gapstur SM, et al. Cigarette smoking and the oral microbiome in a large study of American adults. ISME J 2016 Mar;10(10):2435-2446.
  24. Ertel A, Eng R, Smith SM. The differential effect of cigarette smoke on the growth of bacteria found in humans. Chest 1991 Sep;100(3):628-630.
  25. Reh DD, Higgins TS, Smith TL. Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature. Int Forum Allergy Rhinol 2012 Sep-Oct;2(5):362-369.
  26. Lee KI, Kim DW, Kim EH, Kim JH, Samivel R, Kwon JE, Ahn JC, Chung YJ, Mo JH. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model. Am J Rhinol Allergy 2014 May-Jun;28(3):208-214.
  27. Kumar PS, Matthews CR, Joshi V, de Jager M, Aspiras M. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun 2011 Nov;79(11): 4730-4738.
  28. Namiot Z, Namiot DB, Kemona A, Gołebiewska M, Bucki R. The effect of cigarette smoking and alcohol consumption on efficacy of Helicobacter pylori eradication. Pol Arch Med Wewn 2000 Sep;104(3):569-574.
  29. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. J Gen Intern Med 2002 Mar;17(3):230-234.
  30. Lee WK, Ramanathan M Jr, Spannhake EW, Lane AP. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human betadefensin 2 by sinonasal epithelial cells. Am J Rhinol 2007 Nov-Dec;21(6):658-663.
  31. Kamath PM, Shenoy VS, Mittal N, Sharma NK. Microbiological analysis of paranasal sinuses in chronic sinusitis—a south Indian coastal study. Egypt J Ear Nose Throat All Sci 2013 Nov;14(3):185-189.
  32. Bezerra TF, Pádna FG, Ogawa AI, Gebrim EM, Saldiva PH, Voegels RL. Biofilms in chronic rhinosinusitis with nasal polyps: pilot study. Braz J Otorhinolaryngol 2009 Nov- Dec;75(6):788-793.
  33. Hashemi M, Sadeghi MMM, Omrani MR, Torabi MA. Microbiology and antimicrobial resistance in chronic resistant rhino sinusitis with or without polyp after functional endoscopic sinus surgery. J Res Med Sci 2005;10(3):167-171.
  34. Farahani F, Youse Mashouf R, Hashemian F, Esmaeili R. Antimicrobial resistance patterns of aerobic organisms in patients with chronic rhinosinusitis in Hamadan, Iran. Avicenna J Clin Microb Infec 2014 Aug;1(2):e18961..
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.